|
KMID : 1103720210820030626
|
|
Journal of the Korean Society of Radiology
2021 Volume.82 No. 3 p.626 ~ p.637
|
|
|
Cerebrovascular Reservoir and Arterial Transit Time Changes Assessed by Acetazolamide-Challenged Multi-Phase Arterial Spin Labeling Perfusion MRI in Chronic Cerebrovascular Steno-Occlusive Disease
|
|
Hwang In-Pyeong
Sohn Chul-Ho
Jung Keun-Hwa
Yeon Eung-Koo
Lee Ji-Ye
Yoo Roh-Eul
Kang Koung-Mi
Yun Tae-Jin
Choi Seung-Hong
Kim Ji-Hoon
|
|
|
Abstract
|
|
|
Purpose: To explore cerebrovascular reservoir (CVR) and arterial transit time (ATT) changes using acetazolamide-challenged multi-phase arterial spin labeling (MP-ASL) perfusion-weighted MRI in chronic cerebrovascular steno-occlusive disease.
Materials and Methods: This retrospective study enrolled patients with chronic steno-occlusion who underwent acetazolamide-challenged MP-ASL between June 2019 and October 2020. Cerebral blood flow, CVR, basal ATT, and ATT changes associated with severe stenosis, total occlusion, and chronic infarction lesions were compared.
Results: There were 32 patients (5 with bilateral steno-occlusion) in our study sample. The CVR was significantly reduced during total occlusion compared with severe stenosis (26.2% ± 28.8% vs. 41.4% ± 34.1%, respectively, p = 0.004). The ATT changes were not significantly different (p = 0.717). The CVR was marginally lower in patients with chronic infarction (29.6% ± 39.1% vs. 38.9% ± 28.7%, respectively, p = 0.076). However, the ATT was less shortened in patients with chronic infarction (?54 ± 135 vs. ?117 ± 128 ms, respectively, p = 0.013).
Conclusion: Acetazolamide-challenged MP-ASL provides an MRI-based CVR evaluation tool for chronic steno-occlusive disease.
|
|
|
KEYWORD
|
|
|
Acetazolamide, Cerebrovascular Circulation, Cerebrovascular Disorders, Magnetic Resonance Angiography, Perfusion
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
  
|
|